Abstract: The novel coronavirus pandemic has resulted in unprecedented challenges to the social and psychological well-being of sexual and gender minority (SGM) communities in the US and around the world. For example, data collected from US households in 2020 demonstrated higher rates of job loss and economic uncertainty among SGM as compared to their heterosexual and cisgender counterparts, including severe challenges with accessing healthcare. In this presentation, trends in social and mental health among diverse SGM communities will be discussed including data from two studies collected during the pandemic with SGM women. In the study one, Dr. Cerezo and her team explored how social media impacted SGM women’s mental health, sense of community and alcohol use at one and two months into shelter-in-place. In study two, they examined pandemic stress and vaccination hesitancy among SGM women in Los Angeles county.